amp-activated protein kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1828	Kahweol		Apoptosis , NF-κB , AMPK
	Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity.		Apoptosis , NF-κB , AMPK
TN1100	Nepodin		transporter , COX , AMPK , Parasite
	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 tra...		transporter , COX , AMPK , Parasite
T3889	Platycodin D		Prostaglandin Receptor , AMPK
	Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1...		Prostaglandin Receptor , AMPK
T8476	RSVA405	RSVA 405	AMPK , STAT , Autophagy
	RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor		AMPK , STAT , Autophagy
T7327	7-Methoxyisoflavone		AMPK
	7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).		AMPK
T2374	HTH-01-015		AMPK
	HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).		AMPK
T7362	O-304		AMPK
	O-304 is a pan-activator of AMP-activated protein kinase (AMPK).		AMPK
T4S0800	Demethyleneberberine		P450 , NOS , NF-κB , HIF , AMPK
	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...		P450 , NOS , NF-κB , HIF , AMPK
T16099	MK8722		AMPK
	MK8722 is an effective and systemic activator of pan-AMPK.		AMPK
T6285	GSK-690693	GSK690693	Serine Protease , Akt , PKC , AMPK , Autophagy
	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.		Serine Protease , Akt , PKC , AMPK , Autophagy
T3881	Vaccarin		Integrin , Akt , PERK , AMPK
	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.		Integrin , Akt , PERK , AMPK
T3904	Gomisin J		Calcium Channel , AMPK
	Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK...		Calcium Channel , AMPK
T6291	WZ4003		AMPK
	WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 other kinases.		AMPK
T13411	ZLN024		AMPK
	ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).		AMPK
T11947	MARK4 inhibitor 1		Apoptosis , Others , AMPK
	MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.		Apoptosis , Others , AMPK
T5187	MK-3903	MK 3903	AMPK
	MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).		AMPK
T13173	TMPA		Others , AMPK
	TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.		Others , AMPK
T5497	AMAROGENTIN		Apoptosis , AMPK
	Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis		Apoptosis , AMPK
T4427	PF-06409577	PF 06409577	AMPK
	PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).		AMPK
T2468	A-769662	A 769662	AMPK , Fatty Acid Synthase
	A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).		AMPK , Fatty Acid Synthase